Job Description

**Job Description** The Data, AI, and Genome Sciences (DAGS) department at our company is seeking a highly motivated and skilled data scientist to join our Translational Immunology Analytics team based in San Diego, CA. This individual will play a crucial role in analyzing and interpreting complex multi-omics datasets in immune-mediated diseases generated using various high-throughput platforms. The ideal candidate will possess a deep understanding of computational biology, statistical methods, AI/ML, and bioinformatics pipelines, with a proven track record of independently developing and applying advanced computational approaches to extract meaningful biological insights from integrated multi-omics data in immunologic diseases. This is an exciting opportunity to contribute to groundbreaking research and drive discoveries in complex immune-mediated diseases to inform novel target identification, elucidate mechanisms of target of interests, and support indication expansion strategies. **In this exciting role, you will:** + Develop, implement, and optimize computational pipelines for the processing, and analysis of a wide variety of patient-derived and preclinical multi-omics data to advance our company's Immunology portfolio (e.g., bulk RNAseq, single cell RNAseq, spatial Tx, imaging and HT proteomics). + Apply advanced statistical inference and AI/ML methods for identification and prioritization of novel therapeutic targets and pharmacodynamic biomarkers in immune-mediated diseases. + Design and execute computational studies to elucidate molecular mechanisms of drug action (MoA), disease pathogenesis, and therapeutic response, leveraging multi-modal data in immunology. + Either develop novel computational tools and algorithms or adopt cutting-edge and scalable computational biology and data science approaches to integrate muti-resolution (bulk, single cell, spatial) transcriptomic and epigenomic profiling data derived from patient tissues and preclinical models to decode disease biology across immunological diseases. + Identify and establish advanced AI/ML approaches to leverage single-cell multi-omics data to decode cell-type specific molecular networks with the goal of novel target and biomarker discovery in immunological diseases. + Collaborate closely with experimental biologists to understand biological questions, design analysis strategies, and interpret results in the context of drug discovery and development in immunology. + Effectively communicate complex computational findings to both computational and experimental colleagues through clear visualizations, reports, and presentations. + Contribute to the preparation of manuscripts, presentations, and intellectual property filings. + Maintain meticulous documentation of codes, pipelines, and analyses. **Qualifications:** **Education:** + Ph.D. in Computational Biology, Bioinformatics, Biostatistics, Computer Science or a related field and a minimum of 2 years of postdoctoral or industry research experience in data science or bioinformatics in immunology and/or immuno-oncology **Required Experience and Skills:** + Deep understanding of complex immunological disorders with knowledge of the latest research and trends in the field. + Demonstrated expertise to decode immune-related disease biology by leveraging advanced AI/ML and/or statistical inference frameworks to analyze multi-modal (transcriptomic, epigenomic) and multi-scale (bulk, single-cell and/or spatial) patient-derived data. + Strong data visualization skills with experience using relevant software packages (e.g., ggplot2, matplotlib, Seurat/Scanpy visualization tools). + Excellent problem-solving, critical thinking, and analytical skills. + Strong written and oral communication skills, with the ability to clearly explain complex technical concepts to diverse audiences. + Ability to work independently and collaboratively within a multidisciplinary team. **Preferred Experience and Skills:** + Experience with cloud computing platforms (e.g., AWS, Google Cloud, Azure) and high-performance computing environments. + Demonstrable strong computational background with extensive experience in programming languages such as Python and R. Proficiency in other languages (e.g., C++, Java). + Knowledge of specific biological domains relevant to immune-mediated diseases with an emphasis on molecular mechanisms and therapeutic strategies. + Experience in network analysis, graph theory, and applying systems biology approaches for analyzing biological interactions and pathways. + Experience in developing and deploying robust bioinformatics pipelines. + Familiarity with database management and data warehousing concepts, particularly for integrating diverse biological and clinical datasets. + Familiarity with drug-target interaction databases and resources relevant to pharmaceutical research. + Experience with clinical trial data analysis or patient stratification strategies for indication expansion. + Experience with version control systems (e.g., Git). \#EligibleforERP Current Employees apply HERE ( Current Contingent Workers apply HERE ( **US and Puerto Rico Residents Only:** Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here ( if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights ( EEOC GINA Supplement​ We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts ( **U.S. Hybrid Work Model** Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote". The salary range for this role is $126,500.00 - $199,100.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at . You can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. **San Francisco Residents Only:** We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance **Los Angeles Residents Only:** We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance **Search Firm Representatives Please Read Carefully** Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. **Employee Status:** Regular **Relocation:** Domestic/International **VISA Sponsorship:** Yes **Travel Requirements:** 10% **Flexible Work Arrangements:** Not Applicable **Shift:** 1st - Day **Valid Driving License:** No **Hazardous Material(s):** N/A **Required Skills:** Bioinformatics, Cloud Computing, Computational Biology, Computer Science, Data Science, Data Visualization, Epigenomics, Immunology, Immuno-Oncology, Machine Learning, Transcriptomics **Preferred Skills:** **Job Posting End Date:** 07/31/2025 ***A job posting is effective until 11:59:59PM on the day** **BEFORE** **the listed job posting end date. Please ensure you apply to a job posting no later than the day** **BEFORE** **the job posting end date.** **Requisition ID:** R354304

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Holiday work, For contractors, Local area, Remote job, Relocation, Visa sponsorship, Flexible hours, Shift work, 3 days per week,

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