Staff Bioinformatics Production Scientist - Job at Twist BioScience, South San Francisco, CA

L01qLy9vTFZoRmhEWGRDRlZ1YWhReUlNSXc9PQ==
  • Twist BioScience
  • South San Francisco, CA

Job Description

Senior/ Staff Bioinformatics Production Scientist (Hybrid in South San Francisco)
Position Overview

We are seeking a highly motivated, results-oriented, and collaborative individual to join our Bioinformatics and Analytics team as a Senior/Staff Bioinformatics Production Scientist . In this role, you will combine genomics expertise with strong production engineering skills to design and implement robust, scalable computational pipelines for large-scale NGS data processing and interpretation.

This role is critical in advancing our bioinformatics capabilities to ensure best-in-class performance for Twist Bioscience's production pipelines. You will be responsible for architecting high-throughput workflows , maintaining reliable bioinformatics infrastructure , and collaborating with Field Application Scientists (FAS) to optimize pipelines that directly support customer needs and field operations.

Job title and compensation will be determined based on several factors, including but not limited to position level, individual skills, knowledge, experience, and abilities; the location of the role; internal equity; and alignment with market data.

Key Responsibilities
Pipeline Design & Implementation
  • Develop and maintain production-grade bioinformatics pipelines for NGS data processing using modern workflow frameworks (e.g., Nextflow, Airflow).
  • Ensure pipelines are scalable, reproducible, and optimized for high-throughput sequencing data.
  • Integrate best practices in software development, including CI/CD, containerization (Docker, Singularity), and cloud-based execution .
  • Work directly with Field Application Scientists (FAS) to understand their workflow needs and translate them into robust, user-friendly bioinformatics solutions .
System Architecture & Production Engineering
  • Lead architectural decisions for bioinformatics workflows in cloud-based or on-prem environments.
  • Collaborate with DevOps teams to maintain monitoring, logging, and alerting systems for pipeline reliability and performance.
  • Design and implement data storage solutions for large-scale genomic datasets, balancing accessibility, cost, and efficiency.
  • Develop standardized deployment methods for field-facing applications and pipeline updates.
Collaboration & Cross-Functional Support
  • Partner with FAS teams to troubleshoot pipeline-related issues and improve field operations.
  • Work closely with wet-lab scientists and assay development teams to provide bioinformatics insights for product troubleshooting and optimization.
  • Collaborate with other Senior Bioinformatics Scientists to ensure consistency in data processing pipelines and best practices .
Required Qualifications
  • Education & Experience:
    • Master's degree with 6-8 years of industry experience , or a Ph.D. with 3+ years of industry experience in Bioinformatics, Computational Biology, Computer Science, or a related field .
  • Bioinformatics & Production Pipeline Expertise:
    • Experience designing, implementing, and optimizing production-scale bioinformatics pipelines for NGS data.
    • Strong understanding of workflow orchestration frameworks (e.g., Nextflow, Snakemake, Airflow).
    • Hands-on experience with large-scale genomic data processing and storage solutions .
    • Background in assay development, genomics-based diagnostics, or quality control for high-throughput NGS data .
  • Software Development & DevOps Skills:
    • Proficiency in Python .
    • Strong familiarity with containerization (Docker, Kubernetes), CI/CD, and cloud platforms (AWS, GCP, or Azure) .
    • Experience with monitoring, logging, and alerting tools for bioinformatics workflows.
  • Cross-Functional Collaboration & Support:
    • Ability to work closely with Field Application Scientists , translating field needs into scalable computational solutions.
    • Strong troubleshooting skills and the ability to identify, debug, and resolve pipeline-related challenges in a high-throughput environment.
Preferred Qualifications
  • Experience with Rust, C++, SQL/dbt is a plus
  • Strong grasp of infrastructure automation, cloud-native workflows, and scalable computing architectures .
  • Familiarity with databases (SQL, dbt) and distributed computing frameworks .
  • Experience with high-performance computing (HPC) environments and storage optimization strategies .
About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as "writing" DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers. Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law. San Francisco applicants: Pursuant to the San Francisco Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records.

The base cash compensation for this California-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensation amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensation may be different in other locations.

San Francisco Bay Area Pay Range

$160,314—$209,649 USD

Job Tags

Similar Jobs

NMI Group

Sports-Minded Entry Level Manager Job at NMI Group

 ...The Entry Level Manager will work on the Marketing and Sales team, supporting the Senior Account Executive, Account Supervisor, Management Supervisor, Account Director, and senior team members in day-to-day client business management. This role will lead the monthly campaigns... 

Sunshine Chevrolet

Service Technician (Arden) Job at Sunshine Chevrolet

 ...to our customers and community, offering a wide selection of cars and trucks and no-hassle pricing. Our goal is to provide the best car buying and service experiences for our customers. At Sunshine Chevrolet we pride ourselves on being the most reliable and trustworthy... 

TruBlue Home Service Ally

Handyman/Home Service Technician PART TIME Job at TruBlue Home Service Ally

 ...office support TruBlue of Royal Oak is a Home Ally Service company dedicated to...  ...handyman services with bonded and insured technicians, giving our customers peace of mind. Our...  ...Bathroom upgrades / remodel Drywall repair / patching/ caulking Flooring repair and... 

Kinder Morgan

Operator, Level 1-4 (Rotating Shift) Altamont, UT Job at Kinder Morgan

 ...Position DescriptionThis posting is for an Plant Operator with a hiring range basedon experience and skill set. The position will...  ...for the installation, operation, and maintenance of natural gas pipelines, compression stations and related field operations.... 

The Now

Apply Today, Start Tomorrow - Entry Level Sales & Customer Service Rep Job at The Now

 ...exciting and well-known clients in the world today. Our direct methods are capable of...  ...Opportunities OUR CULTURE : The daily work environment at our Firm is fun, fast-paced...  ...Ability to step outside your comfort zone Start Immediately No experience is required....